Querrey knows what to expect from Murray, who has an excellent record against big servers and will play his 10th consecutive Wimbledon quarter-final.
Murray's preparations had been hindered by a sore hip and although the 30-year-old had previously downplayed the seriousness of the issue, the effects of the problem finally caught up with him against Querrey.
"I don't feel like the hopes of America are on my shoulders", Querrey, who also made the 2016 quarterfinals here, said earlier this week.
Those questioning the quality of the lawns aren't limited to competitors who have rarely played on the grass but include former Wimbledon champions, although Mattek-Sands' description of her injury in a Facebook live video suggested the grass wasn't to blame.
And while he has been winning matches, potential opponents have been losing theirs. Yes, he can. He's the champion, he's in the quarter-final, he has all the shots.
Kevin Anderson also looked depleted by the fifth against Sam Querrey.
It will be the first meeting between the two players at Wimbledon. Murray has come out and said that he does not like playing against a player with the style that Querrey has, but Murray has won seven out of eight of those matches and looks to make it to the semifinals with another big win today. The Scot continues to hirple gingerly around the baseline between points and only sparingly displayed his full power yesterday. There is Roger Federer with all the shots in the book, using his tennis racquet like a paint brush. "I hit 25 winners in total, which is a lot better than it was the other day".
"The next day I beat Milos Raonic to two and zero, and then had a great match with Rafa Nadal in the semis, even though I lost".
"I absolutely respect Angelique Kerber is number one in the world, Muguruza is a former finalist, grand slam victor but we are spoilt for choice". If there's better matches on the men's side, then that has to go first, as well, ' he added.
COULD this be a case of after the Lord Mayor's show for Gilles Muller? Querrey has won 10 of his last 13 matches on grass court.
The All England Club defended the scheduling, saying the men's big four - Murray, Roger Federer, Rafael Nadal and Novak Djokovic - were the marquee players that broadcasters and spectators wanted to see most.
Quarter-finals at Wimbledon are nothing new for Marin Cilic.
Ladbrokes, meanwhile, has Murray at 10/3, again behind Federer and Djokovic.
Prediction: Murray in four sets.
Not all women players were upset by the scheduling either and Magdalena Rybarikova risked a frosty locker-room reception. "I mean, the last two matches, you know, more than anything I felt like I kind of scrapped through at points".
'It's unlike other grand slams. Against Djokovic, he's found life particularly hard with a miserable record of just two wins from their 27 meetings.
It's telling that the American whose name and face is advertised on billboards and posters around SW19 is a guy who retired 11 years ago, Andre Agassi.