Arsenal are likely to recall a host of first-team regulars for the short trip. Despite getting off to a great start in the Europa League on Thursday, securing a 3-1 win over FC Koln, Arsenal's league form has been somewhat lacklustre as they now lie in 13th in the league standings, but it is still early days. The team that has less of these wins the title.
Mourinho, however, had claimed that it has become "trendy to play with five defenders", casually lumping the Italian's wing-backs - lauded for their consistent ability to create width higher up the pitch - in with the three standard centre-backs.
Arsenal have earned convincing home victories over all their main Premier League rivals in recent seasons but have continued to struggle in big games away from the Emirates.
Those both came at Wembley in the FA Cup final in May and the Community Shield in early August.
Chelsea midfielder Danny Drinkwater is expected to be out until the October global break. Antonio Conte is set to make rotational changes to his side, having rested a few players in their game against FK Qarabag.
Antonio Conte, meanwhile, is still unwilling to risk Eden Hazard following his lengthy lay-off with an ankle injury - the Belgium worldwide will start the fixture on the bench.
It is with this in mind, coupled with the Gunners' atrocious start to the season which has seen them beaten 1-0 at Stoke City and humiliated 4-0 at Anfield by Liverpool, that Merson has selected his combined Arsenal and Chelsea XI for tomorrow's clash at Stamford Bridge.
Alexis Sanchez will feature after playing the whole game on Thursday night, where Theo Walcott (calf) hobbled off. Francis Coquelin (hamstring) and Santi Cazorla (ankle) are definitely out.
Chelsea have scored in 23 successive Premier League games at Stamford Bridge with over half of these (12) seeing them score three or more goals.